Your Pain Tolerance May Have Been Passed Down From Neanderthals

Gene variants inherited from Neanderthals can impact pain tolerance and nose shape in modern humans. What else could they influence?

There’s a little bit of Neanderthal in most of us. Neanderthals and Homo sapiens had a long history of intermingling, before the former went extinct about 40,000 years ago. That mixing means most modern humans have some amount of Neanderthal DNA—and it accounts for up to 3% of the genome in some people.

While these genetic remnants don’t have much impact on our day-to-day lives, they may be responsible for one surprising effect: pain tolerance. Recent research shows that people with Neanderthal variants in the gene SCN9A have a lower pain tolerance than people without the gene.

This isn’t the only Neanderthal remnant that’s been passed down. A study from earlier this year pinpointed a certain genome region that impacts nose shape. Taller, wider noses were passed down from our Neanderthal ancestors who lived in colder climates. A larger nose warmed air before it hit the sensitive lungs. 

Ira speaks with Dr. Kaustubh Adhikari, assistant professor of statistics at the Open University in the United Kingdom, who worked on both of these studies. 

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