Placenta Research May Help Explain Pregnancy Loss

By studying placentas from lost pregnancies, one doctor hopes to provide answers that are so often lacking after a miscarriage or stillbirth.

Content warning: This interview includes discussion of miscarriage and pregnancy loss, and may be triggering for some listeners.

The placenta is an incredible body part. It’s the only organ grown temporarily, created during pregnancy and discarded after birth. It has the enormous job of supporting the growth of a fetus, protecting it from infection and inflammation. When something goes wrong with the placenta, it can result in the loss of a baby.

For something that can be so devastating to expectant parents, miscarriages are incredibly normal. Of the 5 million pregnancies each year in the United States, about 1 million end in miscarriage, categorized as a loss before 20 weeks of gestation. About 20,000 pregnancies end in stillbirth during the later stages of gestation.

Often, after a pregnancy loss, doctors tell parents that the cause is unexplained. This can lead to feelings of failure and guilt, even though pregnancy loss is almost always out of a person’s control.

Dr. Harvey Kliman, director of the Yale School of Medicine’s Reproductive and Placental Research Unit, has dedicated his career to better understanding the placenta and its relationship to pregnancy loss. Dr. Kliman and his team recently analyzed 1,256 placentas that resulted in pregnancy loss. They learned that 90% of these losses could be explained by conditions such as a small or misshapen placenta.

Dr. Kliman joins guest host Flora Lichtman to talk about his research, and the importance of studying the placenta as a way to better understand what leads to miscarriage and stillbirth.