Roanoke: That Time 100 People Vanished for No Reason

So... we still don't know what happened, you guys.  BUT 420ish years ago, a bunch of white people tried to form a colony in present-day North Carolina.  It didn't go great. The dude whose idea it was LEFT, and when he came back, everyone was gone.  We have no idea what happened to them... but it won't stop us from guessing.  You're welcome.